Download e-book for kindle: Biomaterials:An Introduction by J. Park

By J. Park

ISBN-10: 0306401037

ISBN-13: 9780306401039

This new version has been accelerated and up to date to incorporate extra smooth issues, and contains new examples, illustrations, difficulties, and case reports.

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Over the years, with the development of more sophisticated fabrication techniques, a number of these microfluidic components have been integrated on a single substrate to automate and perform a complex series of unit operations for biochemical analysis [9]. Applications include DNA analysis [10], gas chromatography [11], chemical microreactors [12], forensic analysis [13], environmental analysis [14], and drug discovery [3]. Micro-total-analysis-systems offer a number of potential advantages when compared to conventional systems, including lower fabrication costs due to massively parallel fabrication techniques, reduced reagent consumption and dead-volume, and improved performance due to the possibility of per- 38 Noori, Upadhyaya, and Selvaganapathy forming multiple analyses on a single chip [15].

In the future, healthcare providers will likely shift from treating diseases to anticipating and preventing them. Widespread screening or testing will be a necessity for such a system, and microfluidic platforms are the most plausible technology for successful implementation. Consider, for example, genetic screening of newborn children for indications of potential health risks. For a quick, orderof-magnitude approximation of the number of tests that might be required each year for such analysis in the United States alone, we can multiply the approximate number of genes times an estimated number of variants per gene [81], times the number of births each year [82] and arrive at 103 x 102 x 106 = 1011 tests per year.

Other successful microfluidic products used in research labs and hospitals include the GeneXpert® system by Cepheid for amplifying and detecting target DNA, the Triage® BNP test by Biosite for assessing the severity of a heart failure, and the iSTAT® 1 system by Abbott for conducting rapid, comprehensive blood screening with minimal sample volumes. Microdevices for liquid dispensing have been developed in various formats by TTP Labtech, Perkin Elmer, Tecan, and Labcyte. These liquid dispensers can manipulate vol- 28 Sommer et.

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