By Martin Scholz
Successful biofunctional floor engineering will confirm the way forward for clinical units akin to orthopedic implants, stents, catheters, vaccine scaffolds, wound dressings, and extracorporeal move units. in addition, the biosensor and diagnostic chip know-how will evolve speedily a result of transforming into scientific want for custom-made drugs. an important obstacle in those applied sciences is the necessity for terminally sterilized items. despite the fact that, novel and secure applied sciences, together with coupling, stabilization, and safety of effector molecules, let terminal sterilization with no sensible loss. This e-book presents a complete review at the state-of-the-art and the way forward for biofunctional floor engineering and is of significant curiosity for these operating within the fields of medication and scientific devices.
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Extra resources for Biofunctional Surface Engineering
Radiation sterilization. In Pharmaceutical Dosage Forms: Parenteral Medications, 3rd ed, Volume 2: Facility Design, Sterilization and Processing (Nema S and Ludwig JD, ed). New York: Informa Healthcare. pp. 268–294. Falconer RJ, Chan C, Hughes K, Munro TP. 2011. Stabilization of a monoclonal antibody during purification and formulation by addition of basic amino acid excipients. J Chem Technol Biotechnol 86: 942–948. htm Garrison WM, Jayko ME, Bennett W. 1962. Radiation-induced oxidation of protein in aqueous solution.
2008). 3 shows that bacterial colonies are visible on all samples that did not incorporate gramicidin A. Samples with gramicidin A in the outer layer reveal total absence of bacteria, indicating that the peptide molecules get in close contact with the bacteria, penetrate their membrane, induce the formation of pores, and consequently cause bacterial lysis. In contrast, another PLL layer on the top of the gramicidin A layer seems to slightly promote cell adhesion but leads to swollen or lysed bacteria.
When samples were lyophilized and irradiated in SPS, irradiation-mediated aggregates and degradation products were found to be markedly reduced. SEC analysis showed that either irradiation type induced severe aggregation and degradation of Herceptin in the original formulation but not in SPS-formulated samples, thus confirming the findings by SDS-PAGE and fluorescent aggregation tests. Interestingly, even at 40 kGy irradiation, the content of high molecular weight aggregates was around 2% or less when SPS-formulated samples were irradiated at −80°C.
Biofunctional Surface Engineering by Martin Scholz