Read e-book online Artificial Organs PDF

By Gerald Miller

ISBN-10: 1598290487

ISBN-13: 9781598290486

ISBN-10: 1598290495

ISBN-13: 9781598290493

The alternative or augmentation of failing human organs with synthetic units and platforms has been a huge point in overall healthiness deal with numerous many years. Such units as kidney dialysis to reinforce failing kidneys, synthetic center valves to exchange failing human valves, cardiac pacemakers to reestablish general cardiac rhythm, and middle support units to enhance a weakened human middle have assisted hundreds of thousands of sufferers within the prior 50 years and gives lifesaving expertise for tens of hundreds of thousands of sufferers every year. major advances in those biomedical applied sciences have regularly happened in this interval, saving a number of lives with leading edge applied sciences. each one of those synthetic organ structures could be defined intimately in separate sections of this lecture.

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For circumstances where there is a need for a demand style pacemaker, there must be two leads placed within the heart as seen in Figure 41. The sensing electrode is placed within the atrium to sense any variation in normal sinus rhythm, such as what might occur during exercise of increased heart activity. The stimulating electrode might be placed within the ventricle and the rate of stimulation is dependent on the sensed SA nodal rate. Modern demand pacemakers thus have four main functions: • Stimulate cardiac depolarization • Sense intrinsic cardiac function • Respond to increased metabolic demand by providing rate responsive pacing • Provide diagnostic information stored by the pacemaker.

Cls 36 QC: IML/FFX T1: IML July 11, 2006 10:53 ARTIFICIAL ORGANS FIGURE 39: Unipolar pacemaker lead. ” The insulation on pacemaker leads is either silicone or polyurethane. Silicone is inert, biocompatible, biostable, repairable with medical adhesive, and has a long and successful history in biomedical applications. Polyurethane is also biocompatible, but additionally has a higher tear strength, lower friction coefficient, and a smaller required thickness. Pacemaker systems that are fixed rate often utilize a single lead that is placed in the atrium (if there is an SA nodal problem) or the ventricle for AV nodal or bundle branch problems.

1 CARDIAC ELECTROPHYSIOLOGY The heart weighs between 7 and 15 ounces (200–425 g) and is a little larger than the size of your fist. 5 billion times. In fact, each day, the average heart beats 100 000 times, pumping about 2000 gallons (7571 L) of blood. Electrical impulses from your heart muscle (the myocardium) cause your heart to contract, and are created by the movement of ions (principally potassium) across membranes in a fashion called depolarization of cells. This depolarization is propagated along pathways as the ion transport continues.

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Artificial Organs by Gerald Miller


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