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Polycythemia in childhood. Am J Dis Child 1933;46:1356–1367. 3. Damon A, Holub DA. Host factors in polycythemia vera. Ann Intern Med 1958;49:43–60. 4. Mohri H. Acquired von Willebrand disease in patients with polycythemia rubra vera. Ann J Hematol 1987;25:135–46. 5. Videback A. Polycythemia vera. Course and prognosis. Acta Med Scand 1950;138:179. 6. Michiels JJ, Drenth JPH. Erythromelalgia: a review of clinical manifestations in pathophysiology. Am J Med 1991;91:416. 7. Talbott JH. Gout and blood dyscrasias.

We concluded that imatinib is useful for treating erythrocytosis and controlling splenomegaly in a significant proportion of patients with PV, but it is less effective for controlling thrombocytosis or splenomegaly in others (101–103). These data suggest heterogeneity of hematopoietic stem cell proliferation in PV or patient variability with respect to imatinib metabolism. Dosage increases above 400 mg/day were usual and doses as high as 800 mg/day were associated with fluid retention, periorbital edema, and diarrhea.

For example, androgen use requires monitoring of serum prostate-specific antigen in men, liver function tests in both men and women, and underscoring the possibility of masculinizing side effects in women. Similarly, the use of thalidomide requires strict supervision and any possibility of pregnancy during its use must be prevented. Other side effects of thalidomide include somnolence, constipation, rash, and neuropathy. Lenalidomide is myelosuppressive and can result in neutropenic fever and sepsis.

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ADI Carrageenan by wahyu-r


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